A simple synthesis of 1-aminophosphonic acids from 1-hydroxyiminophosphonates with NaBH4 in the presence of transition metal compounds
AS Demir, C Tanyeli, O Sesenoglu, S Demic, OO Evin
article (Uluslararası, Hakemli) | Yazar(lar): AS Demir, C Tanyeli, O Sesenoglu, S Demic, OO Evin | Yıl: 1996 | Dergi/Kurum: TETRAHEDRON LETTERS | İndeks: WOS.IC, WOS.CCR, WOS.SCI — Özet: A new procedure has been developed for the synthesis of 1-aminophosphonic acids. Diethyl phosphonates are converted to hydroxyiminoph
A new procedure has been developed for the synthesis of 1-aminophosphonic acids. Diethyl phosphonates are converted to hydroxyiminophosphonates when treated with hydroxylamine hydrochloride. Reduction of hydroxyiminophosphonates with NaBH4 in MeOH in the presence of MoO3 or NiCl2 and hydrolysis of 1- aminophosphonates gave 1-aminophosphonic acids in good yield.