Effects of Photobiomodulation Application on Glutathione-Related Antioxidant Defense System in Rabbit Eye Tissues
Mehmet Ozcan, A. Burus, Y. Bayazit, Etkin Boynuyogun, Mert Calis, Figen Ozgur
article (Uluslararası, Hakemli) | Yazar(lar): Mehmet Ozcan, A. Burus, Y. Bayazit, Etkin Boynuyogun, Mert Calis, Figen Ozgur | Yıl: 2024 | Dergi/Kurum: JOURNAL OF BIOPHOTONICS | İndeks: WOS.SCI | DOI: 10.1002/jbio.202400261 | Anahtar Kelimeler: antioxidant, eye, glutathione, lipid peroxidation, photobiomodulation, ROS —
Photobiomodulation (PBM) has emerged as a potentially effective therapeutic approach to modulate cellular functions. This study aimed to examine the impact of PBM on reactive oxygen species (ROS), lipid peroxidation, and glutathione-related antioxidant defense systems in rabbit eye tissues. A polychromatic light source with an intensity of 2.6 J/cm2/min was used for PBM treatment in New Zealand White rabbits for 12 min. The PBM group (n = 8) received treatments every 2 days for a total of 12 sessions, whereas the control group (n = 8) did not undergo any PBM light exposure during the same period. The application of PBM significantly elevated ROS-mediated glutathione levels, along with increased activities of glutathione peroxidase and reductase, particularly in corneal tissue (p <= 0.05). In conclusion, PBM treatment effectively enhances antioxidant defense mechanisms in the eye, particularly in corneal tissue, suggesting its potential as a therapeutic strategy for managing oxidative stress-related ocular conditions.
The impacts of photobiomodulation on glutathione-related antioxidant defense system in eye tissues. image