Short and Long-Term Prognostic Significance of Galectin-3 in Patients with ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Ugur Kokturk, Hamdi Pusuroglu, Mustafa Umut Somuncu, Ozgur Akgul, Begum Uygur, Sinem Ozyilmaz, Ozgur Surgit, Aydin Yildirm, Nilgun Isiksacan
article (Uluslararası, Hakemli) | Yazar(lar): Ugur Kokturk, Hamdi Pusuroglu, Mustafa Umut Somuncu, Ozgur Akgul, Begum Uygur, Sinem Ozyilmaz, Ozgur Surgit, Aydin Yildirm, Nilgun Isiksacan | Yıl: 2023 | Dergi/Kurum: ANGIOLOGY | İndeks: WOS.SCI | DOI: 10.1177/00033197221149846 — Özet: This study evaluated the short and lo
This study evaluated the short and long-term prognostic value of galectin-3 in patients with ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI). Patients (n = 143) were admitted with STEMI and followed up for 2 years. The study population was divided into high and low galectin-3 groups based on the admission median value of serum galectin-3. Primary clinical outcomes consisted of cardiovascular (CV) mortality, non-fatal reinfarction, stroke, and target vessel revascularization (TVR). CV events were recorded in hospital and at 1 and 2 years. The primary clinical outcomes (in-hospital, 1 year and 2 year) were significantly higher in the high galectin-3 group. (P = .008, P = .004, P = .002, respectively). High galectin-3 levels were also associated with heart failure development and re-hospitalization at both 1 year (P = .029, P = .009, respectively) and 2 years (P = .019, P = .036, respectively). According to Cox multivariate analysis, left ventricular ejection fraction (LVEF) was an independent predictor of 2-year cardiovascular mortality (P = .009), whereas galectin-3 was not (P = .291). Although high galectin-3 levels were not independent predictors of long-term CV mortality in patients with acute STEMI who underwent primary PCI, it was associated with short-term and long-term development of adverse CV events, heart failure, and re-hospitalization.