Comparative Analysis of NF-κB it the MyD88-Mediated Pathway After Implantation of Titanium Alloy and Stainless Steel and the Role of Regulatory T Cells
Sibel Akyol, B. Ben Nissan, Mehmet Yigit Akgun, M. Yetmez, Murat Hanci, F. N. Oktar
article (Uluslararası, Hakemli) | Yazar(lar): Sibel Akyol, B. Ben Nissan, Mehmet Yigit Akgun, M. Yetmez, Murat Hanci, F. N. Oktar | Yıl: 2020 | Dergi/Kurum: WORLD NEUROSURGERY | İndeks: WOS.SCI | DOI: 10.1016/j.wneu.2020.08.016 | Anahtar Kelimeler: Immunology, Inflammatory signal, Instrumentation, Metal implant, NE-kap
OBJECTIVE: Development of immunologically smart implants, integrated to biological systems, is a key aim to minimize the inflammatory response of the host to biomaterial implants.
METHODS: The aim of this study is to investigate the influence of titanium alloy and stainless steel implants on immunological responses in rats by comparative analysis of nuclear factor kappa B (NF-kappa B) profiles in the activation of inflammatory signaling pathways and the role of CD4+CD25+Foxp3+.
RESULTS: Both Ti alloy and stainless steel alloy group implantation affect Toll-like receptors-4 pathways and CD4+CD25+ regulatory T cells in different ways.
CONCLUSIONS: Results show that NF-kappa B/p65 and NF-kappa B1/p50 possess potential as a therapeutic target in the prevention of adverse reactions to metal, especially for controlling inflammation after the implantation.