Synthesis, Characterization, and Antiproliferative Activity Studies of Novel Benzimidazole-Imidazopyridine Hybrids as DNA Groove Binders
Bahar Caymaz, Ufuk Yildiz, Z Gercek, A Sengül, Burak Coban, Senem Akkoc
article (Uluslararası, Hakemli) | Yazar(lar): Bahar Caymaz, Ufuk Yildiz, Z Gercek, A Sengül, Burak Coban, Senem Akkoc | Yıl: 2020 | Dergi/Kurum: CHEMISTRYSELECT | İndeks: WOS.SCI | DOI: 10.1002/slct.202001580 | Anahtar Kelimeler: Antiproliferative, Benzimidazole, Bis-benzimidazole, DNA cleavage, DNA groove binder, Elec
A novel benzimidazole-imidazo[1,2-a]pyridine hybrid; 2-(imidazo[1,2-a]pyridine-8-yl)benzimidazole and its symmetrical bis- derivative 2,2 '-bis-(imidazo[1,2-a]pyridine-8-yl)-1H,1H '-[5,5 ']-bisbenzimidazole were synthesized and characterized. It was found that these two compounds have a strong DNA groove binding and peroxide mediated DNA-cleavage properties. Furthermore, these molecules were screened against three different human cell lines namely HepG2, DLD-1 and MDA-MB-231, and these compounds were found to have high cytotoxic activities.