<i>N</i>-triterpene Saponins in Cancer Therapy: a Review of Mode of Action
Idris Arslan, Ana M. Cenzano
article (Uluslararası, Hakemli) | Yazar(lar): Idris Arslan, Ana M. Cenzano | Yıl: 2020 | Dergi/Kurum: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | İndeks: WOS.SCI | DOI: 10.1007/s43450-020-00033-5 | Anahtar Kelimeler: N-triterpene saponin (NTS), Cancer therapy, Drug discovery, ANO1 inhibitor
Saponins are commonly found in higher plant parts, particularly in roots, tubers, leaves, and seeds, butN-triterpene saponins are rarely found in nature. Here, we focus on molecular structures and anticancer properties particularly in synergistic effects of toxicity, ion channel inhibitory, and opioid receptor modulatory effects of N-triterpene saponins.