Cognitive involvement in clinically isolated syndrome and relationship with fatigue
Bilge Cinar, Pinar Yigit, Serkan Ozakbas, M. Anil Gurkan, Ozan Ozturk
article (Uluslararası, Hakemli) | Yazar(lar): Bilge Cinar, Pinar Yigit, Serkan Ozakbas, M. Anil Gurkan, Ozan Ozturk | Yıl: 2019 | Dergi/Kurum: CUKUROVA MEDICAL JOURNAL | İndeks: WOS.ESCI | DOI: 10.17826/cumj.558000 | Anahtar Kelimeler: Clinically isolated syndrome, cognition, fatigue — Özet: Purpose: The cognitive prof
Purpose: The cognitive profile in clinically isolated syndrome (CIS) is frequently characterized by deficit in processing speed and working memory. In this study, we aimed to investigate the characteristics and frequency of cognitive impairment in patients with CIS by comparing with healthy controls.
Materials and Methods: All participants were tested with PASAT, COWAT, Stroop test, RAVLT, JLO, Trail Making Test, Digit Span. Depression, fatigue and life quality were assessed by the scales.
Results: In this study, 25 patients with CIS and 22 healthy controls matched by age and sex were included. Fifty-two percent of patients were failed at Stroop test in comparison to healthy controls, and this rate was indicated as 60% in COWAT. The frequency of cognitive impairment for the RAVLT, JLO, Trail Making Test, and Digit Span was relatively lower. Moreover, this rate was 20% in PASAT. The cognitive impairment was found in two subtests of BICAMS at least, in 21% of patients. Those with at least one abnormal tests were shown 64% (1SD), 48% (-2SD). There was a significant relationship between the fatigue and cognitive impairment in patients with CIS.
Conclusion: Cognitive impairment was found in two or more sub-tests of BICAMS; in 21% of our group. Attention and executive functions were distinctly found to be impaired in CIS, and cognitive fatigue was related to Stroop, PASAT and COWAT. The existence, frequency and detailed description of the cognitive impairment that has an impact on social life and disease course in the course of CIS should be taken into consideration.