Epileptic seizures in cerebral venous sinus thrombosis: Subgroup analysis of VENOST study
Derya Uluduz, Birsen Ince, Hatice Kurucu, Baki Goksan, I. Midi, Taskin Duman, Sena Colakoglu, Vildan Yayla, Murat Cabala, Ali Yavuz Karahan, Nazire Afsar, Eylem Ozaydin Goksu, Firdevs Ezgi Tokuc, Necdet Mengulluoglu, Emrah Aytac, M. A. Sungur, Nilufer Yesilot, Osman Ozgur Yalin, Taskin Gunes, Serdar Oruc, Mehmet Yaman, Mehmet Guney Senol, Arda Yilmaz, Hamit Genc, Mustafa Gokce, Uygar Utku, Seden Demirci, Ozge Yilmaz Kusbeci, Gulnur Uzuner, Nevzat Uzuner, Hale Zeynep Batur Caglayan, Bijen Nazliel, Mustafa Acikgoz, Fatma Nida Tascilar, Fatih Ozdag, Hakan Tekeli, Serkan Demir, Sevim Baybas, Hayriye Kucukoglu, Ahmet Hakan Ekmekci, Serefnur Ozturk, Vedat Ali Yurekli, Sevki Sahin, Nilgun Cinar, Hesna Bektas, Yuksel Kablan, B Karakurum, Aysel Milanlioglu, Dilek Necioglu Orken, Ufuk Aluclu, Ahmet Tufekci, Mustafa Bakar, Hasan Huseyin Kozak, Cemile Handan Misirli, Fusun Mayda Domac
article (Uluslararası, Hakemli) | Yazar(lar): Derya Uluduz, Birsen Ince, Hatice Kurucu, Baki Goksan, I. Midi, Taskin Duman, Sena Colakoglu, Vildan Yayla, Murat Cabala, Ali Yavuz Karahan, Nazire Afsar, Eylem Ozaydin Goksu, Firdevs Ezgi Tokuc, Necdet Mengulluoglu, Emrah Aytac, M. A. Sungur, Nilufer Yesilot, Osman Ozgur Y
Purpose: The aim of this study is to evaluate the presence and prognostic impact of early seizures in cerebral venous sinus thrombosis patients (CVST).
Method: VENOST is a retrospective and prospective national multicenter observational study. CVST patients with or without epileptic seizures (ES) were analyzed and compared in terms of demographic and imaging data, causative factors, clinical variables, and prognosis in a total of 1126 patients.
Results: The mean age of the patients in the ES group was 39.73 +/- 12.64 and 40.17 +/- 14.02 years in the non-ES group (p > 0.05). Epileptic seizures were more common (76.6 %) in females (p < 0.001). Early ES occurred in 269 of 1126 patients (23.9 %). Epileptic seizures mainly presented in the acute phase (71.4 %) of the disease (p < 0.001). Majority of these (60.5 %) were in the first 24 h of the CVST. The most common neurological signs were focal neurologic deficits (29.9 %) and altered consciousness (31.4 %) in the ES group. Superior sagittal sinus (SSS) and cortical veins (CV) involvement were the most common sites of thrombosis and the mostly related etiology were found puerperium in seizure group (30.3 % vs 13.9 %). Patients with seizures had worse outcome in the first month of the disease (p < 0.001) but these did not have any influence thereafter.
Conclusions: In this largest CVST cohort (VENOST) reported female sex, presence of focal neurological deficits and altered consciousness, thrombosis of the SSS and CVs, hemorrhagic infarction were risk factors for ES occurrence in patients with CVST.