Oxidative stress markers are increased in non-alcoholic fatty liver disease patients with high serum alanine aminotransferase levels
Suzan Muratoglu Severcan, Ayse Bilgihan, Ugur Ercin, Gulbanu Erkan, Cinar Severcan
article (Uluslararası, Hakemli) | Yazar(lar): Suzan Muratoglu Severcan, Ayse Bilgihan, Ugur Ercin, Gulbanu Erkan, Cinar Severcan | Yıl: 2019 | Dergi/Kurum: MEDICAL STUDIES-STUDIA MEDYCZNE | İndeks: WOS.ESCI | DOI: 10.5114/ms.2019.91245 | Anahtar Kelimeler: inflammation, oxidative stress, alanine aminotransferase, non-a
Introduction: Non- alcoholic fatty liver disease (NAFLD) is a pathological disease that causes chronic damage in the liver without alcohol consumption.
Aim of the research: To determine oxidative stress and inflammation statuses (NAFLD) with increased alanine aminotransferase (ALT).
Material and methods: Oxidative stress (malondialdehyde (MDA), advanced oxidation protein products (AOPP), inflammation (serum tumour necrosis factor-alpha (TNF-alpha)), interleukin-6 (IL-6), and hyaluronic acid (HA) were measured by the ELISA method or manually. A total of 133 non-obese and non-diabetic individuals were included. Patients diagnosed with NAFLD with normal ALT levels were included in group 1 (n = 53), and those with high ALT levels were included in group 2 (n = 35). The control group included individuals without any known systemic disease (n = 45).
Results: We found that the serum MDA levels were significantly elevated in group 2 in comparison to the control group (p < 0.05). However, there were no significant changes in the serum AOPP levels in any group (p > 0.05). The serum TNF-a and IL-6 levels of group 1 and group 2 were higher than those in the control group (p < 0.05). The serum HA levels in group 2 increased significantly in comparison to the other groups (p < 0.05).
Conclusions: HA and MDA were enhanced with high ALT levels and with elevated TNF-alpha and IL-6 levels without high ALT levels in NAFLD.