Development of multilayered biomimetic bone plates: In vitro release assessment
R. Seda Tigli Aydin, Seda Uyanik
article (Uluslararası, Hakemli) | Yazar(lar): R. Seda Tigli Aydin, Seda Uyanik | Yıl: 2019 | Dergi/Kurum: JOURNAL OF MATERIALS RESEARCH | İndeks: WOS.SCI | DOI: 10.1557/jmr.2018.447 | Anahtar Kelimeler: strontium, silver, coating, simulated body fluid, bone plate — Özet: In this study, Sr-incorporated nano-assembled hy
In this study, Sr-incorporated nano-assembled hydroxyapatite structures (HASr) on 316L stainless steel bone plates were prepared by a biomimetic method induced by 10x simulated body fluid (SBF). First, HASr was coated on bone plates by the interaction of ions with 10x SBF containing different concentration of strontium ions. Then, silver coating is achieved as a second layer on bone plates. The cumulative release of strontium ions (Sr2+) and silver ions (Ag+) from multilayered HASr-Ag bone plates at the end of 15 days was in the range of 0.016-0.085 mM and 0.064-0.135 mM, respectively. The release mechanism for the bone plates was evaluated by several mathematical models that best fit the release data. The results showed that Sr2+ and Ag+ are released from multilayered bone plates by diffusion, whereas the release of Ag+ is not occurred by diffusion, instead the mechanism is dissolution, when silver is coated alone on bone plates.