Does Sericin, as a Novel Pleurodesis Agent, Have Higher Effectiveness Compared to Talcum Powder, Doxycycline, and Silver Nitrate Pleurodesis?
Alkin Yazicioglu, Mehmet Subasi, Erdal Yekeler, Serkan Uysal, Tuba Sahinoglu, Funda Demirag
article (Uluslararası, Hakemli) | Yazar(lar): Alkin Yazicioglu, Mehmet Subasi, Erdal Yekeler, Serkan Uysal, Tuba Sahinoglu, Funda Demirag | Yıl: 2019 | Dergi/Kurum: ARCHIVOS DE BRONCONEUMOLOGIA | İndeks: WOS.SCI | DOI: 10.1016/j.arbres.2018.10.003 | Anahtar Kelimeler: Sericin, Talcum powder, Doxycycline, Silver nitrate
Introduction: The usefulness of sericin as pleurodesis agent has previously been described. Present study aims to compare sericin pleurodesis regarding success, effectiveness, tolerability, and side-effects.
Methods: Adult, 12-week-old Wistar-albino rats (n = 60), divided to five groups as sericin, talcum-powder, doxycycline, silver-nitrate and control. Agents were administrated through left thoracotomy, rats sacrificed twelve-days after.
Results: Highest ratio of collagen fibers was observed in sericin group, and the intensity was higher than talcum-powder group (p < 0.05). Compared to silver nitrate, sericin group displayed better mesothelial reaction, and multi-layer mesothelium was also better (p < 0.05). Foreign body reaction and emphysema were less frequent in sericin group (p < 0.05). The presence of biological tissue in parenchyma was less prominent in sericin group (p < 0.05). Foreign body reaction on thoracic wall was less common in sericin group (p < 0.05). Presence of biological tissue glue in thoracic wall was less prominent in sericin group (p < 0.05).
Glomerular degeneration was lower in sericin group compared to the silver nitrate group (p < 0.05), and tubular degeneration was less common in sericin group than talcum group (p < 0.05). Pericarditis was less common in sericin group compared to the other groups (p < 0.05).
Conclusion: As an intrinsic, natural glue protein, sericin protects the lung parenchyma and tissues, and its glue-like characteristics enable pleurodesis. The success of sericin in pleurodesis was demonstrated in the present study based on investigations of the pleurae. Being cost-effective and better tolerated agent associated with a low potential of side effects, sericin is more effective, less expensive and provides more lung parenchyma protection. (C) 2018 SEPAR. Published by Elsevier Espana, S.L.U. All rights reserved.