Chronic lymphocytic thyroiditis and tumor-infiltrating lymphocytes combined in thyroid papillary carcinoma
Nilufer Onak Kandemir, F Barut, Sibel Bektas, Banu Dodan Gun, Burak Bahadir, Gamze Yurdakan, Sukru Oguz Ozdamar, Sevinc Hallac Keser, Nimet Karadayi
article (Uluslararası, Hakemli) | Yazar(lar): Nilufer Onak Kandemir, F Barut, Sibel Bektas, Banu Dodan Gun, Burak Bahadir, Gamze Yurdakan, Sukru Oguz Ozdamar, Sevinc Hallac Keser, Nimet Karadayi | Yıl: 2009 | Dergi/Kurum: TURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY | İndeks: WOS.ESCI | Anahtar Kelimeler: Lymphocy
OBJECTIVES
This study examined the frequency of chronic lymphocytic thyroiditis (CLT) in thyroid papillary carcinomas (TPC) and the relationship between the presence of tumor-infiltrating lymphocytes (TIL) and CLT.
METHODS
The study included 61 TPC cases. In each case, the presence of the lymphocyte infiltration in the tumor tissue and nonneoplastic parenchyma was graded semi-quantitatively using a scale of 0 to 3. The cases were classified in two groups, TPC including CLT (Group I) and TPC not including CLT (Group II).
RESULTS
CLT was detected in 26.3% (Group I) of the TPCs and TIL was observed in 77% of the Group I cases; no lymphoid infiltration compatible with TIL was detected in Group II. A significant difference was observed in the TIL density between Groups I and II.
CONCLUSION
CLT is a frequent finding in TPC, and the presence of TIL is related to CLT.