Effects of omeprazole in caffeine and phentylenetetrazole-induced generalized seizures in mice
Gunnur Ozbakis Dengiz, Zekai Hailci, Aysegul Bakirci
article (Uluslararası, Hakemli) | Yazar(lar): Gunnur Ozbakis Dengiz, Zekai Hailci, Aysegul Bakirci | Yıl: 2007 | Dergi/Kurum: ERCIYES MEDICAL JOURNAL | İndeks: WOS.ESCI | Anahtar Kelimeler: Caffeine, Carbonic anhydrase inhibitors, Convulsive seizures, Omeprazole, Pentylenetetrazole — Özet: Purpose: Because omeprazole h
Purpose: Because omeprazole has a carbonic anhydrase inhibitor activity, it was aimed to investigate whether omeprazole has anticonvulsant effect on caffeine and phentylenetetrazole (PTZ)-induced generalize seizures in mice.
Material and Methods: Omeprazole (0.25-0.5-1-2 mg/kg), diazepam (0.5 mg/kg for PTZ model and 5 mg/kg for caffeine model) and distilled water were administrated, 30 min later caffeine (300 mg/kg) or PTZ (100 mg/kg) were injected to all groups, intraperitoneally. Following the caffeine or PTZ injections, the time taken for the onset of the animals' first generalize tonic- clonic convulsion was measured in second, was accepted as the latency period. Tolerance potential of omeprazole were done with 0.5 mg/kg (upon repeated administrated) in caffeine-induced convulsion model.
Results: Following the caffeine and PTZ injections, omeprazole prolonged the latency periods in comparison with caffeine and PTZ groups. The longest latency was observed by omeprazole 0.5 mg/kg dose in the caffeine model (307.47 %, p < 0.05), and omeprazole had showed more protective effect in caffeine seizures than in PTZ seizures. In the tolerance study, latency periods were shortened by omeprazole on following days.
Conclusion: Low doses of omeprazole, in especially caffeine-induced seizures, presented an anticonvulsant activity, but tolerance across to this action developed as the other carbonic anhydrase inhibitors.