Comparison of serum androgens and endometrial thickness in obese and non-obese postmenopausal women
Ilker Arikan, A Barut, Muge Harma, Mehmet Ibrahim Harma, Deniz Cemgil Arikan, Serpil Bozkurt
article (Uluslararası, Hakemli) | Yazar(lar): Ilker Arikan, A Barut, Muge Harma, Mehmet Ibrahim Harma, Deniz Cemgil Arikan, Serpil Bozkurt | Yıl: 2010 | Dergi/Kurum: JOURNAL OF THE TURKISH-GERMAN GYNECOLOGICAL ASSOCIATION | İndeks: WOS.ESCI | DOI: 10.5152/jtgga.2010.23 | Anahtar Kelimeler: Serum androgene, endometrial
Objective: In this study, we investigated whether serum androgen levels and endometrial thickness differed in obese and non-obese women.
Material and Methods: Thirtytwo non-obese (BMI <30) and 48 obese ( BMI 30) women were enrolled. Blood samples were analyzed for testosterone, free testosterone, androstenedione, DHEAS, and SHBG, and transvaginal ultrasonography was performed.
Results: Obese women had significantly higher free testosterone and endometrial thickness and significantly lower SHBG. Eight of 17 women with endometrial thickness >5 mm had significant pathology.
Conclusion: These results suggest that obesity may be a risk factor for endometrial carcinoma and other pathologies in post-menopausal women through an action on androgen concentrations.