The Impact of Surgical Staging on the Prognosis of Mucinous Borderline Tumors of the Ovaries: A Multicenter Study
Kemal Gungorduk, Ozgu Gungorduk, O. Asicioglu, Elena Ioana Braicu, Jumana Almuheimid, Jalid Sehouli, Mustafa Zelal Muallem, Sevki Goksun Gokulu, Ahmet Bilgi, Nuri Yildirim, Levent Akman, Nilufer Cetinkaya, Tayfun Gungor, Zeliha Firat Cuylan, Gonca Pakay, Taylan Senol, Ates Karateke, Elcin Telli, Tufan Oge, Sabit Sinan Ozalp, Tayfun Toptas, Tayup Simsek, Ramazan Ozyurt, Elif Agacayak, Mehmet Sait Icen, Burcu Yucesoy, Aykut Ozdemir, Levent Yasar, Salih Taskin, Ozlem Irak Ovali, Firat Ortac, Aysel Uysal, Anil Turan, Mehmet Ibrahim Harma, Osman Temizkan, Muzaffer Sanci, Onur Erol, Mehmet Mutlu Meydanli
article (Uluslararası, Hakemli) | Yazar(lar): Kemal Gungorduk, Ozgu Gungorduk, O. Asicioglu, Elena Ioana Braicu, Jumana Almuheimid, Jalid Sehouli, Mustafa Zelal Muallem, Sevki Goksun Gokulu, Ahmet Bilgi, Nuri Yildirim, Levent Akman, Nilufer Cetinkaya, Tayfun Gungor, Zeliha Firat Cuylan, Gonca Pakay, Taylan Senol, Ates
Background/Aim: The purpose of this study was to prove the effect of complete surgical staging of patients with mucinous borderline ovarian tumors (mBOTs) especially appendectomy on progression-free survival (PFS) and overall survival (OS). Patients and Methods: The database of 14 gynecological oncology departments from Turkey and Germany were comprehensively searched for women who underwent primary surgery for an ovarian tumor between January 1, 1998, and December 31, 2015, and whose final diagnosis was mBOT. Results: A total of 364 patients with mBOT with a median age of 43.1 years were included in this analysis. The median OS of all patients was 53.1 months. The majority of cases had Stage IA (78.6%). In univariate and multivariate analyses, radical surgery, omentectomy, appendectomy, lymphadenectomy, and adding adjuvant chemotherapy were not independent prognostic factors for PFS and OS. Furthermore, FIGO stage (>= IC vs. <IC), radical surgery, and staging surgery were not independent risk factors for recurrence of mBOTs. Finally, abnormal macroscopic appendix and FIGO stage (>= IC vs. <IC) were independent risk factors for appendiceal involvement (p=0.032). Conclusion: Patients with conservative surgery do not have higher recurrence rates. Fertility-sparing surgery should be considered in the reproductive age group. Detailed surgical staging including lymphadenectomy, appendectomy, and omentectomy does not have an impact on survival rates.