A Multicenter Study of 1144 Patients with Cerebral Venous Thrombosis: The VENOST Study
Taskin Duman, Sena Colakoglu, Derya Uluduz, Baki Goksan, I. Midi, Hesna Bektas, Yuksel Kablan, B Karakurum, Aysel Milanlioglu, Dilek Necioglu Orken, Ufuk Aluclu, Ahmet Tufekci, Mustafa Bakar, Bijen Nazliel, Fatma Nida Tascilar, Hasan Huseyin Kozak, Serkan Demir, Cemile Handan Misirli, Hayriye Kucukoglu, Sevim Baybas, Nilgun Cinar, Fusun Mayda Domac, Serefnur Ozturk, Vildan Yayla, Murat Cabalar, Ali Yavuz Karahan, Nazire Afsar, Eylem Ozaydin Goksu, Firdevs Ezgi Tokuc, Necdet Mengulluoglu, Emrah Aytac, Nilufer Yesilot, Ozgur Osman Yalin, Serdar Oruc, Mehmet Yaman, Seden Demirci, Vedat Ali Yurekli, Arda Yilmaz, Hamit Genc, Mustafa Gokce, Uygar Utku, Ozge Yilmaz Kuspeci, Gulnur Uzuner, Nevzat Uzuner, Birsen Ince, Mehmet Guney Senol, Hale Zeynep Batur Caglayan, Mustafa Acikgoz, Burcu Zeydan, Fatih Ozdag, Ahmet Hakan Ekmekci, Hakan Tekeli, None None
article (Uluslararası, Hakemli) | Yazar(lar): Taskin Duman, Sena Colakoglu, Derya Uluduz, Baki Goksan, I. Midi, Hesna Bektas, Yuksel Kablan, B Karakurum, Aysel Milanlioglu, Dilek Necioglu Orken, Ufuk Aluclu, Ahmet Tufekci, Mustafa Bakar, Bijen Nazliel, Fatma Nida Tascilar, Hasan Huseyin Kozak, Serkan Demir, Cemile Hand
Background: Based on a number of small observational studies, cerebral venous sinus thrombosis has diverse clinical and imaging features, risk factors, and variable outcome. In a large, multicenter cerebral venous thrombosis (VENOST) study, we sought to more precisely characterize the clinical characteristics of Caucasian patients. Methods: All data for the VENOST study were collected between the years 2000 and 2015 from the clinical follow-up files. Clinical and radiological characteristics, risk factors, and outcomes were compared in terms of age and sex distribution. Results: Among 1144 patients 68% were women, and in older age group (>50 years) male patients were more prevalent (16.6% versus 27.8%). The most frequent symptoms were headache (89.4%) and visual field defects (28.9%) in men, and headache (86.1%) and epileptic seizures (26.8%) in women. Gynecological factors comprised the largest group in women, in particular puerperium (18.3%). Prothrombotic conditions (26.4%), mainly methylenetetrahydrofolate reductase mutation (6.3%) and Factor V Leiden mutation (5.1%), were the most common etiologies in both genders. 8.1% of patients had infection-associated and 5.2% had malignancy-related etiology that was significantly higher in men and older age group. Parenchymal involvement constitutively hemorrhagic infarcts, malignancy, and older age was associated with higher Rankin score. Epileptic seizures had no effect on prognosis. Conclusions: Clinical and radiological findings were consistent with previous larger studies but predisposing factors were different with a higher incidence of puerperium. Oral contraceptive use was not a prevalent risk factor in our cohort. Malignancy, older age, and hemorrhagic infarcts had worse outcome. (c) 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.