Leptin levels in children with obstructive sleep apnea syndrome
A Sogut, Serefden Acikgoz, Lokman Uzun, MB Ugur, R Altin, Elif Dagli, Refika Ersu, Athanasios Kaditis
article (Uluslararası, Hakemli) | Yazar(lar): A Sogut, Serefden Acikgoz, Lokman Uzun, MB Ugur, R Altin, Elif Dagli, Refika Ersu, Athanasios Kaditis | Yıl: 2016 | Dergi/Kurum: TUBERKULOZ VE TORAK-TUBERCULOSIS AND THORAX | İndeks: WOS.ESCI | DOI: 10.5578/tt.21009 | Anahtar Kelimeler: Leptin, obstructive sleep apnea syndr
Introduction: The aim of this study is to assess the effect of obstructive sleep apnea syndrome (OSAS) severity on leptin levels in children.
Patients and Methods: Children with habitual snoring underwent overnight polysomnography. Fasting venous blood samples were obtained between 8 AM and 9 AM, following the night of the sleep study. Children with an apnea-hypopnea index of >= 5/h were included in the moderate-to-severe OSAS group while those with an apnea-hypopnea index of < 5/h formed the mild OSAS/primary snoring group.
Results: 47 children (51% male and 49% female; mean age 7.8 +/- 2.6 years) were recruited. Twenty seven participants were diagnosed with moderate-to-severe OSAS, and twenty children who had AHI < 5 were included in the mild OSAS/primary snoring. The two groups did not differ regarding age, gender and body mass index z score (p> 0.05). Furthermore there were no differences in log serum leptin levels (p= 0.749). Log serum leptin levels correlated with the BMI z score in the whole study group (p= 0.001; r= 0.499) but they were not associated with apnea-hypopnea index, mean and lowest oxygen saturation during sleep.
Conclusion: Serum leptin levels are affected by adiposity but not by OSAS severity among children with habitual snoring.