Multiparametric or practical quantitative liver MRI: towards millisecond, fat fraction, kilopascal and function era
Emre Unal, Ilkay Sedakat Idilman, Musturay Karcaaltincaba
article (Uluslararası, Hakemli) | Yazar(lar): Emre Unal, Ilkay Sedakat Idilman, Musturay Karcaaltincaba | Yıl: 2017 — Özet: Introduction: New advances in liver magnetic resonance imaging (MRI) may enable diagnosis of unseen pathologies by conventional techniques. Normal T1 (550-620ms for 1.5T and 700-850ms for 3T), T2,
Introduction: New advances in liver magnetic resonance imaging (MRI) may enable diagnosis of unseen pathologies by conventional techniques. Normal T1 (550-620ms for 1.5T and 700-850ms for 3T), T2, T2* (>20ms), T1rho (40-50ms) mapping, proton density fat fraction (PDFF) (5%) and stiffness (2-3kPa) values can enable differentiation of a normal liver from chronic liver and diffuse diseases. Gd-EOB-DTPA can enable assessment of liver function by using postcontrast hepatobiliary phase or T1 reduction rate (normally above 60%). T1 mapping can be important for the assessment of fibrosis, amyloidosis and copper overload. T1rho mapping is promising for the assessment of liver collagen deposition. PDFF can allow objective treatment assessment in NAFLD and NASH patients. T2 and T2* are used for iron overload determination. MR fingerprinting may enable single slice acquisition and easy implementation of multiparametric MRI and follow-up of patients.Areas covered: T1, T2, T2*, PDFF and stiffness, diffusion weighted imaging, intravoxel incoherent motion imaging (ADC, D, D* and f values) and function analysis are reviewed.Expert commentary: Multiparametric MRI can enable biopsyless diagnosis and more objective staging of diffuse liver disease, cirrhosis and predisposing diseases. A comprehensive approach is needed to understand and overcome the effects of iron, fat, fibrosis, edema, inflammation and copper on MR relaxometry values in diffuse liver disease.