A multiscale model for acid-mediated tumor invasion: Therapy approaches
Christian Stinner, Christina Surulescu, Guelnihal Meral
article (Uluslararası, Hakemli) | Yazar(lar): Christian Stinner, Christina Surulescu, Guelnihal Meral | Yıl: 2015 | Dergi/Kurum: JOURNAL OF COUPLED SYSTEMS AND MULTISCALE DYNAMICS | İndeks: WOS.ESCI | DOI: 10.1166/jcsmd.2015.1071 | Anahtar Kelimeler: Multiscale Model, Acid-Mediated Tumor Invasion, pH-Taxis, Radiotherap
Starting from the two-scale model for pH-taxis of cancer cells introduced previously by the authors, we consider here an extension accounting for tumor heterogeneity w.r.t. treatment sensitivity and a treatment approach including chemo-and radiotherapy. The effect of peritumoral region alkalinization on such therapeutic combination is investigated with the aid of numerical simulations.