Influence of Radiation Exposure During Radiotherapy <i>Evidence for the Increase of Versican and Heparin-Binding EGF-like Growth Factor Concentrations</i>
Mahmut Kemal Ozbilgin, Caner Aktas, Elgin Turkoz Uluer, Mustafa Cagatay Buyukuysal, Manuchehr Salehi Gareveran, Cengiz Kurtman
article (Uluslararası, Hakemli) | Yazar(lar): Mahmut Kemal Ozbilgin, Caner Aktas, Elgin Turkoz Uluer, Mustafa Cagatay Buyukuysal, Manuchehr Salehi Gareveran, Cengiz Kurtman | Yıl: 2016 | Dergi/Kurum: ANALYTICAL AND QUANTITATIVE CYTOPATHOLOGY AND HISTOPATHOLOGY | İndeks: WOS.SCI | Anahtar Kelimeler: cancer, carcinogens,
OBJECTIVE: To investigate the reaction of versican and heparin-binding EGF-like growth factor (HB-EGF) molecule concentrations to acute radiation exposure in normal bladder and rectal tissue samples in order to gain more insight into the effects of cancer radiotherapy.
STUDY DESIGN: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice bladder and rectum tissue samples were subjected to a 10-Gy single-dose radiation exposure in the pelvic region with a Co-60 teletherapy device and investigated 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation.
RESULTS: In the immunohistochemical examination of the tissue samples with anti-versican and anti-HB-EGF primary antibodies was observed a statistically significant increase 7 days after radiation exposure.
CONCLUSION: The observed increase of versican and HB-EGF concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy.