THE EFFECT OF CHANNEL BLOCKING ON FIRST SPIKE TIMING
Rukiye Uzun, M Özer, None None
proceeding (Uluslararası, Hakemli) | Yazar(lar): Rukiye Uzun, M Özer, None None | Yıl: 2015 | Dergi/Kurum: 2015 23RD SIGNAL PROCESSING AND COMMUNICATIONS APPLICATIONS CONFERENCE (SIU) | İndeks: WOS.ISTP | Anahtar Kelimeler: Noise delayed decay, ion channel noise, channel blocking — Özet: We investigate the first-spike
We investigate the first-spike response latency dynamics of a single Hodgkin-Huxley neuron model with a tunable intensity of intrinsic noise and fraction of blocked voltage-gated sodium and potassium ion channels embedded in biological membranes. In contrast to previous studies, we consider a biophysically realistic neuron model which contains stochastic ion channels. We show that potassium ion channels play a key role than sodium ion channels on the appearance of the noise delayed decay (NDD) effect in the first-spike timing.