Omega-3 prevents myelin degeneration in rat foetuses exposed to radiation
U. Erkayiran, A. S. Batioglu, Yusuf Ergun, H. Isik, A. Seven, D. Kayaalp, M. Caydere
article (Uluslararası, Hakemli) | Yazar(lar): U. Erkayiran, A. S. Batioglu, Yusuf Ergun, H. Isik, A. Seven, D. Kayaalp, M. Caydere | Yıl: 2016 | Dergi/Kurum: JOURNAL OF OBSTETRICS AND GYNAECOLOGY | İndeks: WOS.SCI | DOI: 10.3109/01443615.2015.1065230 | Anahtar Kelimeler: Omega-3, magnetic field exposure, pregnant rat —
The aim of this study is to investigate the protective effect of antioxidant omega-3 fatty acid (FA) on demyelinisation and degeneration of nerves in central and peripheral nervous systems (CNS and PNS) of rat foetuses. 38 pregnant rats weighing 140-155 g were used. Rats were divided into five groups. Group 1: 7 rats exposed to radiation treatment (RT) for 1 hour/day only; Group 2: 7 rats exposed to RT + Omega-3 FA (p.o.) for 1 hour/day; Group 3: 7 rats exposed to RT for 4 hours/day; Group 4: 7 rats exposed to RT + Omega-3 FA (p.o.) for 4 hours/day; and Group 5: 10 rats with no treatment. Nerve injury was induced by whole-body exposure to 20-T magnetic field. Omega-3 FA was given orally at a dose of 50 mg/kg. After 18 days, foetuses were delivered by the milking method; CNS and PNS were taken out for pathological examination. The degeneration scores of Group 2 were significantly lower than those of Group 1, whereas the degeneration scores of Group 4 were significantly higher than those of Groups 1 and 3. In conclusion, radiation increases demyelinisation and degeneration of nerves in the rat foetuses' CNS and PNS. Omega-3 FA prevents myelin and nerve degeneration in rat foetuses in low-dose radiation exposure.