Bodipy-based photosensitizers with long alkyl tails at the <i>meso</i> position: efficient singlet oxygen generation in Cremophor-EL micelles
Bilal Kilic, Engin U. Akkaya, Nisa Yesilgul, Veli Polat, Z Gercek
article (Uluslararası, Hakemli) | Yazar(lar): Bilal Kilic, Engin U. Akkaya, Nisa Yesilgul, Veli Polat, Z Gercek | Yıl: 2016 | Dergi/Kurum: TETRAHEDRON LETTERS | İndeks: WOS.SCI, WOS.IC | DOI: 10.1016/j.tetlet.2016.02.033 | Anahtar Kelimeler: Bodipy, Photosensitizers, Singlet oxygen, Organic chromophores, Organic photoc
Bodipy dyes with n-decyloxyphenyl-(4, 5) and pentadecyl-(8) mesa substituents can easily embed themselves into micellar structures formed from Cremophor-EL. In micelles of approximately 20 nm median size, heavy-atom substituted dyes show remarkable photosensitization properties as evidenced by the rate of reaction with an anthracene-based selective singlet oxygen trap in buffered aqueous solutions. Considering the ease of Bodipy derivatization and the advantages of Cremophor-EL carried therapeutic agents, these photosensitizing agents may offer novel targeting opportunities and enhanced chemical and photophysical stability. (C) 2016 Elsevier Ltd. All rights reserved.