Comparison of thiopental and ketamine plus xylazine anesthesia in ischemia/reperfusion-induced arrhythmias in rats
Ersoz Gonca
article (Uluslararası, Hakemli) | Yazar(lar): Ersoz Gonca | Yıl: 2015 | Dergi/Kurum: TURKISH JOURNAL OF MEDICAL SCIENCES | İndeks: WOS.SCI | DOI: 10.3906/sag-1403-25 | Anahtar Kelimeler: Anesthetics, ischemia/reperfusion, ventricular arrhythmias, rat — Özet: Background/aim: To investigate the influence of thiopental (8
Background/aim: To investigate the influence of thiopental (85 mg/kg, intraperitoneally (ip)), and ketamine+xylazine (ketamine 75 mg/kg and xylazine 8 mg/kg, ip) anesthesia on the incidence and duration of ischemia/reperfusion-induced arrhythmias.
Materials and methods: Myocardial ischemia was induced by a 6-min ligation of the left anterior descending coronary artery, followed by a 6-min reperfusion. Measurements were taken of the incidence and duration of ventricular arrhythmias, the mean arterial blood pressure and heart rate, and the pressure rate-product (as an index of myocardial oxygen consumption).
Results: The arrhythmia score and the incidence of ventricular fibrillation and tachycardia were significantly decreased in the ketamine+xylazine-anesthetized rats compared with the thiopental-anesthetized group (arrhythmia score: 2.0 +/- 2.1 versus 3.7 +/- 1.2, P < 0.05). The heart rate was significantly lower in the ketamine+xylazine group during the entire experiment, whilst the pressure-rate product was also significantly lower in the ketamine+xylazine group at different time points of the ischemia and reperfusion periods.
Conclusion: Ketamine+xylazine anesthesia has a strong antiarrhythmic effect and an apparent depressive action on the heart rate and the myocardial oxygen consumption index. Therefore, ketamine+xylazine anesthesia is not appropriate for the evaluation of possible antiarrhythmic agents. Thiopental anesthesia is preferable to ketamine+xylazine anesthesia in the in vivo ischemia-reperfusion arrhythmia model.