Pycnogenol prevents peritoneal adhesions
Ahmet Sahbaz, Oner Aynioglu, Hatice Isik, A Borazan, Osman Cengil, Onur Erol
article (Uluslararası, Hakemli) | Yazar(lar): Ahmet Sahbaz, Oner Aynioglu, Hatice Isik, A Borazan, Osman Cengil, Onur Erol | Yıl: 2015 | Dergi/Kurum: ARCHIVES OF GYNECOLOGY AND OBSTETRICS | İndeks: WOS.SCI | DOI: 10.1007/s00404-015-3764-4 | Anahtar Kelimeler: Pycnogenol, Intra-abdominal, Adhesions, Female, Rat — Özet:
This study tested the ability of pycnogenol, an extract from the bark of the French maritime pine (Pinus pinaster), to prevent intra-abdominal adhesions.
Thirty female Wistar albino rats were separated randomly into three equal groups: Group (1) the control group, which underwent surgery, but was given no drug; Group (2) given 10 mg/kg of pycnogenol dissolved in normal saline intraperitoneally for 10 days after surgery; and Group (3) given 0.1 mL of normal saline for 10 days intraperitoneally after surgery. On post-operative day 10, all of the animals were killed and any adhesions were evaluated macroscopically and histopathologically.
The macroscopic adhesion scores (mean +/- A SD) for Groups 1, 2, and 3 were 2.5 +/- A 0.53, 0.60 +/- A 0.70, and 2.0 +/- A 0.82, respectively. The macroscopic adhesion score was significantly lower in Group 2 than in Groups 1 and 3 (p < 0.001). All three components of the histopathological evaluation (inflammation, fibrosis, and neovascularization) were significantly lower in Group 2 than in Groups 1 or 3 (p < 0.001, p < 0.001, and p = 0.004, respectively).
Pycnogenol was found to be effective at preventing surgery-related adhesions in an animal model.