Unpredicted effects of Ankaferd® on cartilage tissue
Cenk Evren, MB Ugur, Burhan Yildirim, Volkan Bilge Yigit, F Cinar, Sibel Bektas
article (Uluslararası, Hakemli) | Yazar(lar): Cenk Evren, MB Ugur, Burhan Yildirim, Volkan Bilge Yigit, F Cinar, Sibel Bektas | Yıl: 2015 | Dergi/Kurum: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | İndeks: WOS.SCI | Anahtar Kelimeler: Ankaferd, hemostatic agent, cartilage — Özet: Objective: This study
Objective: This study aims to investigate the histopathological changes secondary to the administration of Ankaferd Blood Stopper (R) (ABS) into the auricular cartilage. Materials and methods: Both of the auricular cartilages of thirty New Zealand rabbits were marked with tattoo ink. A 0.2-cc ABS (study group, n: 30) and 0.2 cc physiological saline (control group, n: 30) were subcutaneously infused into the right auricle and left auricle, respectively. All layers were removed at 14 days. Results: The ABS group had significantly higher level of fibrosis, necrosis, foreign body reaction, inflammation, and cartilage degeneration, compared to the controls. Conclusion: Our study results showed that ABS administration into a closed cavity led to a significantly increased fibrosis and necrosis in the auricular cartilage.