Favourable effect of Eugenol on liver histology in acute cholestasis in rats after bile duct ligation
M. Sarikaya, Levent Filik, Bilal Ergul, Z. Dogan, Alparslan M. Gonultas, S. Hucumenoglu, M Can, M. E. Duymus
article (Uluslararası, Hakemli) | Yazar(lar): M. Sarikaya, Levent Filik, Bilal Ergul, Z. Dogan, Alparslan M. Gonultas, S. Hucumenoglu, M Can, M. E. Duymus | Yıl: 2014 | Dergi/Kurum: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY | İndeks: WOS.SCI | DOI: 10.4149/bll_2014_120 | Anahtar Kelimeler: biliary ductular
Background: Eugenol an essential oil found in clove was previously shown to have some anti-inflammatory properties. It also was shown to be linked to hepatoprotective effect. In this regard, we aimed to reveal the effect of eugenol on cholestatic liver disease.
Method: Cholestatic liver disease model was established in 20 rats via bile duct ligation. Eugenol was administered and cytokine levels and liver histology after sacrifice were evaluated.
Results: Binary ductular proliferation and neutropil infiltration were lower in eugenol-administered rats.
Conclusion: Eugenol has a promising effect on liver histology in cholestatic liver disease (Tab. 1, Fig. 2, Ref. 16). Text in PDF www.elis.sk.