Effect of <i>Nigella sativa</i> oil on postoperative peritoneal adhesion formation
Ahmet Sahbaz, Firat Ersan, Serdar Aydin
article (Uluslararası, Hakemli) | Yazar(lar): Ahmet Sahbaz, Firat Ersan, Serdar Aydin | Yıl: 2014 | Dergi/Kurum: JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | İndeks: WOS.SCI | DOI: 10.1111/jog.12172 | Anahtar Kelimeler: adhesion, Nigella sativa oil, peritoneal adhesions, peritoneum, prevention — Özet: AimWe aim to
AimWe aim to evaluate the effect of Nigella sativa oil (NSO) on postoperative peritoneal adhesion formation in female rats. This experimental study is the first on the prevention of postoperative adhesion formation by NSO.
MethodsTwenty-four Wistar albino female rats were randomly assigned to three groups of eight rats each. Rats in group 1 were each injected i.p. with 1mL of NSO. In group 2, an adhesion model was created with no injection of NSO. In group 3, an adhesion model was created and the area was covered with 1mL of NSO. The rats were killed on postoperative day 8, and the severity of adhesions was evaluated macroscopically and histopathologically.
ResultsThere was a statistically significant difference in adhesion scores between group 2 (control) and group 3 (NSO-treated) (P=0.003). Statistically significant differences in angiogenesis, fibrosis and inflammation were observed between the control and Nigella sativa groups (P=0.002, P=0.001 and P=0.004, respectively).
ConclusionCovering peritoneal surfaces with NSO after peritoneal trauma is effective in decreasing peritoneal adhesion formation.