ABO Blood Group and Risk of Pancreatic Cancer in a Turkish Population in Western Blacksea Region
Huseyin Engin, Cemil Bilir, Hasan Ustun, Ayla Gokmen
article (Uluslararası, Hakemli) | Yazar(lar): Huseyin Engin, Cemil Bilir, Hasan Ustun, Ayla Gokmen | Yıl: 2012 | Dergi/Kurum: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | İndeks: WOS.SCI | DOI: 10.7314/apjcp.2012.13.1.131 | Anahtar Kelimeler: Blood group, pancreatic cancer, survival, Turkey — Özet: Background: We aimed
Background: We aimed to investigate the relationship between blood groups and pancreatic cancer in a Turkish population in Western Blacksea region. Methods: This is a retrospective study. Zonguldak Karaelmas University outpatient oncology clinic records were screened for the period between 2004 and 2011. Results: The median age of patients were 56 (+/- 16) and 132 of 633 study population had pancreatic cancer. Pancreatic cancer patients had significantly higher rates of blood group A compared to controls (OR 1.8, 95% CI, p 0.005). Rates of blood group AB was significantly lower than the control group (OR 0.37, 95% CI, p 0.04). The median survival (IR) time in subjects having the blood groups A, B, AB and O were 7.0 (1-28), 7.0 (2-38), 10 (2-36) and 9.0 (2-48) months respectively; the blood group 0 had significantly higher overall survival (OS) compared to the non-0 groups (p 0.04). Conclusions: Pancreatic cancer patients had more common blood group A in our population. Moreover, blood group AB appeared to be a protective factor against pancreatic cancer in our population. Blood group 0 had a significantly longer survival compared to non-0, regardless of prognostic factors.