Lymphatic Differentiation in Classic Kaposi's Sarcoma: Patterns of D2-40 Immunoexpression in the Course of Tumor Progression
Nilufer Onak Kandemir, F Barut, A Borazan, Sukru Oguz Ozdamar, Sevinc Hallac Keser, Nimet Karadayi, Mustafa Ozkan Gun
article (Uluslararası, Hakemli) | Yazar(lar): Nilufer Onak Kandemir, F Barut, A Borazan, Sukru Oguz Ozdamar, Sevinc Hallac Keser, Nimet Karadayi, Mustafa Ozkan Gun | Yıl: 2011 | Dergi/Kurum: PATHOLOGY & ONCOLOGY RESEARCH | İndeks: WOS.SCI | DOI: 10.1007/s12253-011-9392-9 | Anahtar Kelimeler: D2-40, Immunohistochemistry
The recent development of lymphatic endothelium-specific immuno-indicators has given rise to research on the histogenesis of Kaposi sarcoma (KS), specifically focusing on its lymphatic root and differentiation. D2-40 is a new lymphatic marker that recognizes podoplanin and is easily applied to formalin-fixed paraffin-embedded human tissues. This study examined D2-40 immunoexpression in 178 classical KS lesions using immunohistochemical methods. D2-40 immunoexpression was also examined in 63 non-KS soft tissue lesions to test the reliability of D2-40 monoclonal antibody in the pathological diagnosis of KS. D2-40 immunoreactivity was detected at all of the KS lesions and in lymphangioma and nonneoplastic lymphatic endothelium. There was no significant relationship between the extent of D2-40 staining and histopathological stage; however, there was a positive correlation between the staining intensity and histopathological stage in KS cases. D2-40 immunoreactivity was detected at all histopathological stages of KS and may be added to the routine immunohistochemical panel used for the differential diagnosis of KS. Widespread D2-40 protein expression is evidence of a lymphatic origin or the differentiation of neoplastic cells in KS, and D2-40 expression increases with tumor progression.