Acetylsalicylic Acid Loading and Release Studies of the PMMA-<i>g</i>-Polymeric Oils/Oily Acids Micro and Nanospheres
B Çakmakli, Ebru Kilicay, B Hazer, Emir Baki Denkbas, Bektas Acikgoz
article (Uluslararası, Hakemli) | Yazar(lar): B Çakmakli, Ebru Kilicay, B Hazer, Emir Baki Denkbas, Bektas Acikgoz | Yıl: 2011 | Dergi/Kurum: JOURNAL OF APPLIED POLYMER SCIENCE | İndeks: WOS.SCI | DOI: 10.1002/app.32825 | Anahtar Kelimeler: drug release, magnetic polymer micro/nanospheres, polymeric oil/oily acids copo
Poly(methyl methacrylate) (PMMA) and PMMA copolymers derived from plant oils (Polylinseed oil-g-PMMA, Polysoybean oil-g-PMMA, Polylinoleic acid-g-PMMA (PLina-g-PMMA) and Polyhydroxy alkanoate-sy-g-Polylinoleic acid-g-PMMA (PHA-g-PLina-g-PMMA)) as hydrophobic polymers, a series of hydrophobic microsphere or nanosphere dispersions, were prepared by the emulsion/solvent evaporation method. The diameters of the nanospheres and microspheres were measured by dynamic light scattering with a zetasizer, optically and by scanning electron microscopy. The magnetic quality of the microspheres was determined by the electron spin resonance technique. Acetylsalicylic acid (aspirin, ASA) was used as a model drug and loaded into the microspheres during the preparation process. The effect of the stirring rate over the size and size distribution of the micro/nanospheres was evaluated, and the effects of copolymer types derived from plant oil/oily acids and the copolymer/drug ratios were evaluated. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 119: 1610-1618, 2011