c-Kit (CD117) expression in classic Kaposi's sarcoma
Nilufer Onak Kandemir, N. Ozdemir, Nimet Karadayi, B. D. Gun, Burak Bahadir, Gamze Yurdakan, Sukru Oguz Ozdamar
article (Uluslararası, Hakemli) | Yazar(lar): Nilufer Onak Kandemir, N. Ozdemir, Nimet Karadayi, B. D. Gun, Burak Bahadir, Gamze Yurdakan, Sukru Oguz Ozdamar | Yıl: 2010 | Dergi/Kurum: CLINICAL AND EXPERIMENTAL DERMATOLOGY | İndeks: WOS.SCI | DOI: 10.1111/j.1365-2230.2009.03661.x — Özet: Background. Kaposi's sarcoma is
Background. Kaposi's sarcoma is a multicentric, low-grade, vascular neoplasia. Human herpesvirus 8 is associated with all epidemiological forms of KS and has been shown in vitro to induce the tyrosine receptor kinase c-Kit in infected cells.
Aim. To investigate the expression of c-Kit in cases of classic KS and to clarify its association with clinicopathological parameters and HHV8 latency-associated nuclear antigen-1 expression.
Methods. In total, 35 cases of classic KS at various histological stages were included in the study. Age and gender of the patients and location and histological stage of the tumours were recorded. Formalin-fixed, paraffin wax-embedded tissue sections were stained by immunohistochemistry with antibodies to c-Kit and HHV8.
Results. c-Kit immunoreactivity was found in 22 cases and HHV8 immunoreactivity was present in all cases. There was no correlation in c-Kit immunoreactivity between clinicopathological parameters and HHV8 immunoreactivity.
Conclusions. The results of our study show that in cases of classic KS there is a high rate of c-Kit immunoreactivity, but c-Kit expression does not show any correlation with HHV8 immunoreactivity.