Analysis of peripheral blood lymphocyte phenotypes and Th1/Th2 cytokines profile in the systemic immune responses of <i>Helicobacter pylori</i> infected individuals
Basak Kayhan, M. Arasli, IO Tekin, Haci Eren, Selim Aydemir, Elif Aktas, Burcak Kayhan
article (Uluslararası, Hakemli) | Yazar(lar): Basak Kayhan, M. Arasli, IO Tekin, Haci Eren, Selim Aydemir, Elif Aktas, Burcak Kayhan | Yıl: 2008 | Dergi/Kurum: MICROBIOLOGY AND IMMUNOLOGY | İndeks: WOS.SCI | DOI: 10.1111/j.1348-0421.2008.00066.x | Anahtar Kelimeler: cytokines, gamma delta T cells, helicobacter pylori,
H. pylori elicits specific humoral and cellular immune responses in the mucosal immune system. However, the type and extent of T lymphocyte response in the systemic immune system is not clear for H. pylori positive patients. In this study, peripheral blood T lymphocyte phenotypes and serum Th1/Th2 based cytokines of 32 H. pylori positive patients were analyzed and compared to those of healthy controls. While alpha beta TCR+ lymphocytes and their phenotype analysis were not significantly different to those of healthy controls, the percentage of pan gamma delta TCR+ lymphocytes was up to 2.4 times greater in the H. pylori positive group then in healthy controls. Furthermore, significant increases in IL-10 concentrations in serum samples of H. pylori patients indicated that their immune systems had switched toward a Th2 type immune response. The correlation between phenotype and type of T cell response in the peripheral blood during H. pylori infection is discussed.