Oxidative stress markers, C-reactive protein and heat shock protein 70 levels in subjects with metabolic syndrome
F Armutcu, M. Ataymen, Ahmet Gurel, H Atmaca
article (Uluslararası, Hakemli) | Yazar(lar): F Armutcu, M. Ataymen, Ahmet Gurel, H Atmaca | Yıl: 2008 | Dergi/Kurum: CLINICAL CHEMISTRY AND LABORATORY MEDICINE | İndeks: WOS.SCI | DOI: 10.1515/cclm.2008.166 | Anahtar Kelimeler: carbonyl protein, C-reactive protein, heat shock protein 70, metabolic syndrome, oxidative
Background: The metabolic syndrome is a cluster of cardiovascular risk factors and essential components of metabolic syndrome are hyperglycemia, hypertension, visceral obesity, hypertriglyceridemia and low high-density lipoprotein cholesterol. Oxidative stress plays a critical role in the pathogenesis of metabolic syndrome components and insulin resistance. The aim of this study was to investigate the role of oxidative stress, C-reactive protein and heat shock protein 70 levels in the pathogenesis of this disease.
Methods: A total of 36 patients diagnosed with metabolic syndrome and 33 controls were included in the study. Malondialdehyde, carbonyl protein, C-reactive protein and heat shock protein 70 levels and xanthine oxidase and superoxide dismutase activities were measured in the serum of the subjects.
Results: Mean serum malondialdehyde, carbonyl protein, C-reactive protein (p < 0.01, p < 0.05 and p < 0.001, respectively) and xanthine oxidase activity were significantly higher (p < 0.01) in serum of the patients than the control group. Superoxide dismutase activity and heat shock protein 70 levels were significantly lower (p < 0.01 and p < 0.05, respectively) in serum of the patients.
Conclusions: These results suggest that oxidative stress parameters and components of metabolic syndrome are closely related; therefore, significant alterations may occur in the antioxidant and inflammatory status. However, further studies are required to evaluate the possible molecular mechanisms of heat shock protein 70 levels in metabolic syndrome.