The increase in P-wave dispersion is associated with the duration of disease in patients with Behcet's disease
Sait Mesut Dogan, M Aydin, M Gursurer, Nesligul Yildirim, Tolga Onuk, Rasit Sayin, NS Tekin, C Altinyazar
letter (Uluslararası, Hakemli) — Özet: Aim: P-wave dispersion (PD) has been reported to be associated with inhomogeneous and discontinuous propagation of sinus impulses. Behcet's disease (BD) is a chronic multi-system disease presenting with recurrent oral and genital ulceration, and relapsing uveitis. Left ventricular
Aim: P-wave dispersion (PD) has been reported to be associated with inhomogeneous and discontinuous propagation of sinus impulses. Behcet's disease (BD) is a chronic multi-system disease presenting with recurrent oral and genital ulceration, and relapsing uveitis. Left ventricular diastolic dysfunction, ventricular arrhythmia and sudden cardiac death have been documented in Behcet's disease. The aim of this study was to evaluate myocardial involvement noninvasively in patients with 1313 by measuring PD.
Methods: Study population included 29 patients with BD (group 1), (16 males, mean age: 60.4 +/- 10.1 years), and 45 normal (group 11), (23 males, mean age: 61.2 +/- 12.0 years). The maximum and minimum P-wave duration (Pmax and Pmin) and PD were measured from the 12-lead surface electrocardiogram. Echocardiographic examination was also performed.
Results: There was no statistically significant difference between two groups in respect to age, gender, hypertension, diabetes mellitus, hyperlipidemia and cigarette smoking (p > 0.05). Pmax, and PD of patients with BD were found to be significantly higher than those of control subjects (116.2 +/- 14.0 ms vs. 102.0 +/- 16.5 and 49.3 +/- 12.7 ms vs. 29.3 +/- 8.5 ms, respectively p < 0.0001). Moreover, we found a significant positive correlation between PD with 1313 duration (r=0.78, p < 0.0001).
Conclusion: Pmax and PD are found to be greater in patients with BD than in controls and are related with the duration of the disease. (c) 2007 Elsevier Ireland Ltd. All rights reserved.