Gastroprotective and antioxidant effects of amiodarone on lndomethacin-induced gastric ulcers in rats
Gunnur Ozbakis Dengiz, Fehmi Odabasoglu, Zekai Halici, H. Suleyman, Elif Cadirci, Y. Bayir
article (Uluslararası, Hakemli) | Yazar(lar): Gunnur Ozbakis Dengiz, Fehmi Odabasoglu, Zekai Halici, H. Suleyman, Elif Cadirci, Y. Bayir | Yıl: 2007 | Dergi/Kurum: ARCHIVES OF PHARMACAL RESEARCH | İndeks: WOS.SCI | Anahtar Kelimeler: amiodarone, indomethacin, gastroprotective effect, myeloperoxiclase, antioxidant enzym
Reactive oxygen species (ROS) have been implicated in the etiology-of indomethacin-induced gastric mucosal damage. This study investigated amiodarone's protective effects against oxidative gastric mucosal damage induced by indomethacin. Amiodarone is a widely used antiarrhythmic agent. We have investigated alterations in the glutathione level, and the activities of antioxidative enzymes [superoxide dismutase, catalase, glutathione s-transferase glutathione reductase and myeloperoxidase], as markers for ulceration process following oral administration of amiodarone and ranitidine in rats with indomethacin-induced ulcers. In the present study we found that 1) amiodarone, lansoprazole and ranitidine reduced the development of indomethacin-induced gastric damages, at a greater magnitude for amiodarone and lansoprazole than for ranitidine; 2) arniodarone and ranitidine alleviated increases in the activities of catalase and glutathione s-transferase enzymes resulting from ulcers; 3) arniodarone and ranitidine ameliorated depressions in the glutathione level and the activities of superoxide dismutase and glutathione reductase enzymes caused by indomethacin administration; and 4) all doses of amiodarone amplified the myeloperoxidase activity resulting from indomethacin-induced gastric ulcers. The results indicate that the gastroprotective activity of arniodarone, which may be linked to its intrinsic antioxidant properties, cannot be attributed to its effect on myeloperoxidase activity.