Gastroprotective and antioxidant effects of montelukast on indomethacin-induced gastric ulcer in rats
Gunnur Ozbakis Dengiz, Fehmi Odabasoglu, Zekai Halici, Elif Cadirci, H. Suleyman
article (Uluslararası, Hakemli) | Yazar(lar): Gunnur Ozbakis Dengiz, Fehmi Odabasoglu, Zekai Halici, Elif Cadirci, H. Suleyman | Yıl: 2007 | Dergi/Kurum: JOURNAL OF PHARMACOLOGICAL SCIENCES | İndeks: WOS.SCI | DOI: 10.1254/jphs.fp0070122 | Anahtar Kelimeler: montelukast, indomethacin, gastroprotective effect, myelopero
Montelukast, a selective reversible cysteinyl leukotriene D-4-receptor (LTD4 receptor) antagonist, is used in the treatment of asthma. We have investigated alterations in the glutathione (GSH) and activity levels of antioxidative enzymes [superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), and glutathione reductase (GR)] and myeloperoxidase (MPO), as markers of the ulceration process following oral administration of montelukast, lansoprazole, famotidine, and ranitidine, respectively, in rats with indomethacin-induced ulcers. In the present study, we found that 1) montelukast, lansoprazole, famotidine, and ranitidine all reduced the development of indomethacin-induced gastric damage, with this reduction occurring at a greater magnitude for montelukast, famotidine, and lansoprazole than for ranitidine; 2) montelukast and ranitidine both alleviated increases in the activity levels of CAT and GST enzymes resulting from gastric injury; 3) montelukast and ranitidine both ameliorated depressions in the GSH and activity levels of SOD and GR enzymes caused by indomethacin administration; and 4) all doses of montelukast, lansoprazole, and ranitidine decreased amplification of MPO activity resulting from induced gastric injuries. These results suggest that the gastroprotective effects of montelukast on indomethacin-induced ulcerations can be attributed to its ameliorating effect on oxidative damage and MPO activity.