Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers
Ozden Ozel Guven, Taner Erdogan, Hakan Goker, Sulhiye Yildiz
article (Uluslararası, Hakemli) | Yazar(lar): Ozden Ozel Guven, Taner Erdogan, Hakan Goker, Sulhiye Yildiz | Yıl: 2007 | Dergi/Kurum: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | İndeks: WOS.SCI | DOI: 10.1016/j.bmcl.2007.01.061 | Anahtar Kelimeler: phenyl, 1H-benzimidazole, benzyl ether, antibacterial, antifungal — Özet
In this study, a series of novel phenyl- and benzimidazole-substituted benzyl ethers were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Methicillin-resistant S. aureus (MRSA), Escherichia coli, Candida albicans, and Candida krusei. Compound 6g exhibited the most potent antibacterial activity with lowest MIC values of 3.12 and 6.25 mu g/mL against S. aureus and MRSA, respectively. (c) 2007 Elsevier Ltd. All rights reserved.