Oxidative stress and protein oxidation in pseudoexfoliation syndrome
Ramazan Yagci, Ahmet Gurel, Ibrahim Ersoz, Ugur C. Keskin, Ibrahim F. Hepsen, Sunay Duman, Ramazan Yigitoglu
article (Uluslararası, Hakemli) — Özet: Purpose: To investigate the oxidant/antioxidant status and protein oxidation in pseudoexfoliation syndrome. Methods: The activity of serum superoxide dismutase ( SOD) and the levels of serum malondialdehyde (MDA) and protein carbonyl ( PC) were measured in 50 patients with pseudo
Purpose: To investigate the oxidant/antioxidant status and protein oxidation in pseudoexfoliation syndrome. Methods: The activity of serum superoxide dismutase ( SOD) and the levels of serum malondialdehyde (MDA) and protein carbonyl ( PC) were measured in 50 patients with pseudoexfoliation (PEX) and in 55 healthy controls. Results: There was significant difference in the SOD activity in PEX group compared with the control group ( p < 0.001). In addition, MDA and PC levels were significantly higher in patients than in the controls ( p < 0.001). Conclusions: Decrease in SOD activity and the higher levels of MDA and PC indicate increased oxidative stress. Our results suggest a possible role of oxidative stress in pathology of PEX syndrome.