Letrozole vs. clomiphene citrate in patients with ovulatory infertility
U Bayar, HA Tanriverdi, A Barut, F Ayoglu, O Özcan, E Kaya
article (Uluslararası, Hakemli) | Yazar(lar): U Bayar, HA Tanriverdi, A Barut, F Ayoglu, O Özcan, E Kaya | Yıl: 2006 | Dergi/Kurum: FERTILITY AND STERILITY | İndeks: WOS.SCI | DOI: 10.1016/j.fertnstert.2005.09.045 | Anahtar Kelimeler: letrozole, clomiphene citrate, ovulation induction, ovulatory infertility — Özet: Obj
Objective: To compare the effectiveness of letrozole and clomiphene citrate (CC) in ovulatory patients with borderline male factor infertility, early stage endometriosis, and unexplained infertility.
Design: Prospective quasi-randomized trial.
Setting: University infertility clinic.
Patient(s): Forty-six consecutive patients with ovulatory infertility were recruited. Twenty-five patients (67 cycles) were given CC and 21 patients (52 cycles) were given letrozole. Both drugs were given orally on days 3-7 of menses.
Intervention(S): Letrozole, CC, ovulation induction, IUI, tinted intercourse.
Main Outcome Measure(s): Number of follicles, endometrial thickness, and pregnancy rates.
Result(s): The median serum E, concentration on the day of hCG administration in the letrozole and CC groups were 191.5 pmol/L and 476.0 pmol/L, respectively. The median endometrial thickness on the day of hCG were 8 mm in both groups. Ovulation occurred in 81% (42/52) of the letrozole-treated and 85% (57/67) of the CC-treated patients. Pregnancy rate (PR) per cycle was 9% (5/52) in the letrozole group and 12% (8/67) in the CC group.
Conclusion(s): Letrozole and CC have comparable effectiveness in ovulatory patients with borderline male factor infertility, early stage endometriosis, and unexplained infertility.