Palladium-catalyzed synthesis of 9-(2-cyclopentenyl) guanine
Z Gültekin
article (Uluslararası, Hakemli) | Yazar(lar): Z Gültekin | Yıl: 2006 | Dergi/Kurum: ASIAN JOURNAL OF CHEMISTRY | İndeks: WOS.SCI | Anahtar Kelimeler: carbocyclic nucleosides, carbovir, purities — Özet: The racemic synthesis of the 9-(2-cyclopentenyl) guanine (4) from 2-cyclopentenon was prepared in 4 steps with a good
The racemic synthesis of the 9-(2-cyclopentenyl) guanine (4) from 2-cyclopentenon was prepared in 4 steps with a good yield (43%) and excellent selectivity (N9-isomer). The syntheses were achieved in a convergent and direct manner via palladitim(0) catalysed coupling between 2-amino-6-chloropurine and 2-cyclopentene-1-ethyl carbonate (2). Compounds 2-4 have been characterized by high resolution MS. H-1 NMR and IR.