Chemoenzymatic synthesis of both enantiomers of 2-chloro-1-(2-furyl)ethanol
AS Demir, Z Gercek, D Karakaya
article (Uluslararası, Hakemli) | Yazar(lar): AS Demir, Z Gercek, D Karakaya | Yıl: 2005 | Dergi/Kurum: TETRAHEDRON-ASYMMETRY | İndeks: WOS.SCI, WOS.IC, WOS.CCR | DOI: 10.1016/j.tetasy.2005.04.007 — Özet: Enzyme catalyzed transesterification of rac-2-chloro-1-(2-furyl)ethanol rac-1 using vinyl acetate afforded the enan
Enzyme catalyzed transesterification of rac-2-chloro-1-(2-furyl)ethanol rac-1 using vinyl acetate afforded the enantiomers of 2-chloro-1-(2-furyl)ethanol 1 and 2-chloro-1-(2-furyl)ethyl acetate 2 in high enantiomeric excess. Several lipases were used for the kinetic resolution of racemic 2-chloro-1-(2-furyl)ethanol 1, in which the lipases from Pseudomonas cepacia, Candida antarctica and Candida cylindracea displayed high enantioselectivity towards 1. (C) 2005 Elsevier Ltd. All rights reserved.