The Ala-9Val polymorphism in the mitochondrial targeting sequence (MTS) of the manganese superoxide dismutase gene is not associated with juvenile-onset asthma
Ahmet Gurel, N Tomac, HR Yilmaz, None Tekedereli, O Akyol, F Armutcu, H Yuce, H Akin, N Ozcelik, H Elyas
article (Uluslararası, Hakemli) | Yazar(lar): Ahmet Gurel, N Tomac, HR Yilmaz, None Tekedereli, O Akyol, F Armutcu, H Yuce, H Akin, N Ozcelik, H Elyas | Yıl: 2004 | Dergi/Kurum: CLINICAL BIOCHEMISTRY | İndeks: WOS.SCI | DOI: 10.1016/j.clinbiochem.2004.08.002 | Anahtar Kelimeler: Asthma, oxidative stress, manganese supe
Background: We aimed to investigate the possible association between Mn-SOD polymorphism in the mitochondrial targeting sequence and asthma.
Methods: Alanine or valine polymorphism in the signal peptide of Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with NgoM IV
Results: No significant difference in genotype frequencies was found between patients and controls.
Conclusion: These results suggest no major modifying role for the Mn-SOD gene polymorphism in patients with asthma.
(C) 2004 The Canadian Society of Clinical Chemists. All rights reserved.