An improved non-linear thermodynamic model of voltage-dependent ionic currents
M Özer
article (Uluslararası, Hakemli) | Yazar(lar): M Özer | Yıl: 2004 | Dergi/Kurum: NEUROREPORT | İndeks: WOS.SCI | Anahtar Kelimeler: ion channel, rate constant, thermodynamic model, T-type calcium channel — Özet: Thermodynamic models of ionic currents are used to deduce exact functional form of rate constant. It is first
Thermodynamic models of ionic currents are used to deduce exact functional form of rate constant. It is first assumed that free energy depends linearly on voltage. A major criticism of this approach is that time constant can reach arbitrarily small values resulting in an aberrant behavior. Recently, non-linear effects of electric field on the free energy were considered to solve this problem based on T-type calcium channel. In this study, we show that the current model approximately captures the voltage-dependence of the time constant only in a specific range of voltage and does not provide saturation of the time constant outside this range. Then, we propose an improved non-linear thermodynamic model and illustrate its applicability based on T-type calcium channel.