APPROACH TO KOILOCYTOSIS MECHANISM BY HPV PROTEINS
Zehra Safi Oz
article (Uluslararası, Hakemli) | Yazar(lar): Zehra Safi Oz | Yıl: 2010 | Dergi/Kurum: MARMARA MEDICAL JOURNAL | İndeks: WOS.ESCI | Anahtar Kelimeler: Koilocyte, Human papillomavirus (HPV), Cervico-vaginal smear (PAP) — Özet: Koilos means "hollow" in Greek. Koilocyte is a cell with a big perinuclear halo, characteristi
Koilos means "hollow" in Greek. Koilocyte is a cell with a big perinuclear halo, characteristic of the human papilloma virus (HPV). HPV causes various changes through its structural proteins in the cytoplasms and nuclei of the cells and tissues it infects. Among these cellular changes, koilos formation is influenced by the structural proteins of the virus and tumour suppressor genes. The koilocytes observed in cervico-vaginal smears are considerably important for observing the presence of HPV and early diagnosis of cervical cancer cases due to this virus. Therefore, this research attempts to explain the koilocyte formation mechanism by human papillomavirus proteins and tumour suppressor genes.