Interactions of the aminoglycoside neamine and 2-deoxystreptamine with copper(II) and zinc(II)
GA Lawrance, Y Baran, PM Kau, None None, EI von Nagy-Felsobuki
article (Uluslararası, Hakemli) | Yazar(lar): GA Lawrance, Y Baran, PM Kau, None None, EI von Nagy-Felsobuki | Yıl: 2001 | Dergi/Kurum: INORGANIC REACTION MECHANISMS | İndeks: WOS.SCI | Anahtar Kelimeler: aminoglycoside, copper(II), zinc(II), formation constants, kinetics, electrospray mass spectrometry — Özet: Acid di
Acid dissociation constants for the aminoglycosides neomycin and neamine and of 2-deoxystreptamine are reported. Solution NMR studies indicate that complexation with copper(II) and zinc(II) involves principally the primary amine donors, and formation constants with both neamine and 2-deoxystreptamine (2-DOS) and these metal ions are reported (at 25degreesC, I = 0.5 mol dm(-3)). Complexation studies probed by electrospray mass spectrometry identify both 1:1 and 1:2 species for Cu(II) and Zn(II) with 2-DOS, but only 1:1 species with neamine, consistent with behaviour in bulk solution. Preliminary formation kinetics of Cu(II) with neamine indicate rapid complexation at high pH but slower two-step processes near pH 7, consistent with complications in the thermodynamic determinations in the intermediate pH regime. Reaction of 2-DOS and neamine with Cu(II) in methanol appears as a single process, with the former occurring similar to10(3)-fold faster.